ANTIBIOTIC WHO Essential Verified Rx Required

Penicillin G Benzathine

Also known as:Bicillin L-A
2 Protocols
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Primary Use

First-line treatment for syphilis.

Also Used For:

Strep throat
Rheumatic fever prevention
Other bacterial infections

Drug Classification

Medication Type
ANTIBIOTIC
Drug Class
Penicillin antibiotic

Dosage & Administration

Standard Dosage
2.4 million units
Frequency
Single dose for primary syphilis
Duration
Single injection for early syphilis, multiple doses for late syphilis
Route
INJECTION IM
Important
Administered by healthcare professional

Available Forms

Dosage Forms

INJECTION IM

Available Strengths

2.4 million units

Effectiveness

Success Rate
95%+ cure rate for early syphilis
No significant resistance reported. Remains treatment of choice.

Treatment Protocols

Syphilis - Primary/Secondary (Early Syphilis)

For: SYPHILIS

First-Line
Dosage
2.4 million units
Frequency
Single dose
Duration
1 day
95%+ cure rate

Syphilis - Late Latent/Tertiary

For: SYPHILIS

First-Line
Dosage
2.4 million units
Frequency
Weekly
Duration
3 weeks
90%+ for halting disease progression

Safety Information

Common Side Effects

Injection site painFeverHeadacheRash

Serious Side Effects (Seek Medical Help)

Severe allergic reaction
Anaphylaxis
Jarisch-Herxheimer reaction
Kidney problems

Contraindications (Do Not Use If)

Penicillin allergy
History of anaphylaxis to beta-lactams

Drug Interactions

ProbenecidMethotrexateOral contraceptives

Pregnancy

Category B - Treatment of choice for syphilis in pregnancy

Breastfeeding

Compatible with breastfeeding

Pricing Information

Global Avg. Price
$12
Patent Status
Generic available

Prices may vary significantly by country, pharmacy, and insurance coverage. This is an average estimate.

Availability & Regulations

Prescription Required
Not OTC
Not Controlled

Available In

🇵🇭Philippines🇹🇭Thailand🇻🇳Vietnam🇸🇬Singapore🇲🇾Malaysia🇺🇸United States🇬🇧United Kingdom